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Abstract
Boczek, L.A., C.H. Johnson
and E.W. Rice. 2006. Trimethoprim-sulfamethoxazole resistance in sewage
isolates of Escherichia coli. JEMREST 2:19-25
DOI:
10.4029/2006jemrest2no13
Sewage samples from seven
locations in the United
States were analyzed for Escherichia coli
isolates, which were resistant to the antibiotic
trimethoprim-sulfamethoxazole (TMP-SMX). The prevalence rate of TMP-SMX
resistant organisms varied between the different geographical locales. The
majority of the TMP-SMX resistant E. coli were also resistant to ampicillin
and tetracycline, and exhibited high maximum inhibitory concentration (MIC)
values. Resistant isolates were found in phylogenetic groups associated with
commensal E. coli (phylogenetic groups A and B1) as well as in those groups
associated with extraintestinal infections, including urinary tract
infections (UTIs) (phylogenetic groups B2 and D). Serogrouping indicated that
serogroups most often associated with UTIs were found primarily in the B2 and
D phylogenetic groupings. These findings suggest that commensal E. coli
isolates may serve as a potential reservoir of antibiotic resistance. Studies
of sewage isolates conducted over time may assist in determining indigenous
levels of antibiotic resistance within a community.
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